Sung Choe Selected Research

Enzymes

1/2023	Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial.
1/2021	Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in Combination With Azacitidine for Newly Diagnosed Acute Myeloid Leukemia.
1/2020	Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma.
1/2019	A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
10/2016	Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.
1/2014	Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.

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Sung Choe Research Topics

Disease

15	Neoplasms (Cancer) 01/2023 - 09/2012
8	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2021 - 01/2017
4	Glioma (Gliomas) 07/2023 - 10/2020
4	Hematologic Neoplasms (Hematological Malignancy) 01/2023 - 01/2017
3	Cholangiocarcinoma 11/2021 - 01/2019
2	Carcinogenesis 12/2018 - 04/2012
2	Lung Neoplasms (Lung Cancer) 01/2014 - 08/2013
1	Ascites 11/2021
1	Disease Progression 11/2021
1	Starvation 12/2020
1	Lymphoma (Lymphomas) 12/2020
1	Chondrosarcoma 01/2020
1	Fatigue 01/2019
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2019
1	Disease Resistance 01/2018
1	Cardiomyopathies (Cardiomyopathy) 03/2014
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2014
1	Hypersensitivity (Allergy) 08/2013
1	Osteoporosis 04/2012
1	Bone Diseases (Bone Disease) 04/2012
1	Breast Neoplasms (Breast Cancer) 06/2011
1	Hypoxia (Hypoxemia) 06/2011
1	Glaucoma 01/2008

Drug/Important Bio-Agent (IBA)

12	ivosidenibIBA 07/2023 - 01/2019
8	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2023 - 03/2014
6	EnzymesIBA 01/2023 - 01/2014
4	vorasidenibIBA 07/2023 - 01/2021
4	alpha-hydroxyglutarateIBA 01/2023 - 03/2014
3	enasidenibIBA 01/2021 - 01/2017
2	isocitric acid (isocitrate)IBA 01/2019 - 01/2017
2	Phosphotransferases (Kinase)IBA 08/2013 - 06/2011
2	neratinibIBA 04/2012 - 06/2011
1	Immunoglobulin G (IgG)IBA 01/2023
1	5-hydroxymethylcytosineIBA 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	Azacitidine (5 Azacytidine)FDA Link 01/2021
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 12/2020
1	Dihydroorotate DehydrogenaseIBA 12/2020
1	UridineIBA 12/2020
1	pyrimidineIBA 12/2020
1	Alkaline PhosphataseIBA 01/2019
1	CholesterolIBA 01/2019
1	Phosphorus (Red Phosphorus)IBA 01/2019
1	Squalene Monooxygenase (Squalene Epoxidase)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 12/2018
1	Oxidoreductases (Dehydrogenase)IBA 01/2017
1	Small Interfering RNA (siRNA)IBA 10/2016
1	malic acid (malate)IBA 10/2016
1	Aspartic Acid (Aspartate)FDA Link 10/2016
1	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 10/2016
1	Tricarboxylic AcidsIBA 10/2016
1	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA 04/2016
1	GlutaminaseIBA 01/2014
1	NitrogenIBA 01/2014
1	Glutamine (L-Glutamine)FDA Link 01/2014
1	CarbonIBA 01/2014
1	Cadherins (E-Cadherin)IBA 01/2014
1	VimentinIBA 01/2014
1	NucleotidesIBA 08/2013
1	Thymidine Monophosphate (TMP)IBA 08/2013
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 08/2013
1	thymidine 5'-triphosphate (thymidine triphosphate)IBA 08/2013
1	Serine (L-Serine)FDA Link 09/2012
1	Amino Acids FDA Link 09/2012
1	Glucose (Dextrose)FDA LinkGeneric 09/2012
1	Orphan Nuclear ReceptorsIBA 04/2012
1	Estrogen ReceptorsIBA 04/2012
1	Estrogens (Estrogen)FDA Link 04/2012
1	tyrosine receptor (receptor, tyrosine)IBA 06/2011
1	Proteins (Proteins, Gene)FDA Link 06/2011
1	Paclitaxel (Taxol)FDA LinkGeneric 06/2011
1	DTPPIBA 01/2008
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2008
1	SiliconesIBA 01/2008

Therapy/Procedure

8	Therapeutics 11/2021 - 01/2014
1	Drug Therapy (Chemotherapy) 01/2021